| Date |
Opponent* |
Result |
Record |
|
| Sept. 4, 2010 | at Florida | L | 34-12 | 0-1 | | | Sept. 11, 2010 | Eastern Michigan | W | 28-21 | 1-1 (1-0) | | | Sept. 18, 2010 | Colorado State | W | 31-10 | 2-1 | | | Sept. 25, 2010 | at Missouri | L | 51-13 | 2-2 | | | Oct. 2, 2010 | Kent State | W | 27-21 | 3-2 (2-0) | | | Oct. 9, 2010 | at Cincinnati | L | 45-3 | 3-3 | | | Oct. 16, 2010 | at Central Michigan | W | 27-20 | 4-3 (3-0) | | | Oct. 23, 2010 | Ohio | L | 34-13 | 4-4 (3-1) | | | Oct. 30, 2010 | at Buffalo | W | 21-9 | 5-4 (4-1) | | | Nov. 10, 2010 | at Bowling Green | W | 24-21 | 6-4 (5-1) | | | Nov. 17, 2010 | at Akron | W | 19-14 | 7-4 (6-1) | | | Nov. 23, 2010 | Temple | W | 23-3 | 8-4 | | | Dec. 3, 2010 | Northern Illinois | W | 26-21 | 9-4 (7-1) | | |
| | | | |
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